The developmental cycle of ankylosing spondylitis varies from person to person. First of all, it is important to know that ankylosing spondylitis is a heterogeneous disease, and some patients progress very quickly and some progress very slowly. Other patients have an intermittent progression, with a high level of disease activity at a certain time, and then a long period of quiescence after treatment, with a very slow progression of the disease. It must be clear that ankylosing spondylitis is a disease that continues to develop, and although it may not seem to progress quickly, it will slowly worsen, only the length of the cycle varies from person to person.