Long-term internal use of hormonal drugs can cause many physical injuries, so patients are generally very wary of this. However, little attention has been paid to the harm caused by the external use of hormone drugs. In this regard, topical hormone medications can also cause harm due to side effects. At present, in the process of treating skin diseases, hormonal topical medications such as skin relaxation, de-inflammatory pine, beclomethasone propionate, dermatoprene, dermacare cream, etc. are most widely used. They have anti-inflammatory, anti-allergic, anti-itch effect, can timely control the disease, reduce pain, and promote the improvement of the disease, so many people take these drugs as a panacea for skin disease. In fact, although these drugs are used externally, but if used improperly will be harmed. Such drugs can also produce local or systemic side effects with long-term use, such as local flushing of the skin, capillary dilation, rosacea-like dermatitis, skin atrophy and dryness. Systemic side effects include Cushing’s syndrome and aseptic necrosis of the femur. Topical hormonal medication has its indications like any other medication. It is indicated for allergic allergic skin diseases such as neurodermatitis, eczema, seborrheic dermatitis, limited psoriasis, discoid lupus erythematosus, etc. However, hormonal drugs do not have the effect of killing bacteria, mold and virus, so they cannot be used for bacterial or viral skin diseases, such as impetigo, folliculitis, boils, ringworm, tinea corporis, ringworm, flat warts, common warts, etc. If these patients are treated with hormonal drugs, they will not only be ineffective, but also aggravate their conditions. In addition, hormonal topical medication for allergic skin disease has a rapid anti-inflammatory, anti-itch, timely control of the disease to reduce the pain, but can not be the root cause of the cure, easy to relapse after discontinuation of the drug, and therefore must be accompanied by other drugs treatment. Different parts of the human body have different skin permeability, so different concentrations of hormone topical drugs should be used according to different parts. For example, for the face, ears and external genitalia, it is appropriate to use low concentration and low efficacy drugs; patients who need long-term maintenance drugs should first use high efficacy drugs and then switch to low efficacy drugs after the condition is controlled, because the higher the efficacy, the greater the side effects and the harm caused; patients who need long-term hormone drugs can also use intermittent drugs or alternate several hormone drugs to prevent drug resistance.