The redness and swelling of the skin after squeezing the blackhead is likely to be secondary infection, can be used to mupirocin ointment and other anti-inflammatory drugs applied locally to reduce the swelling, the serious need for oral medication or incision and drainage. Due to individual differences, the effect can not be generalized, there is no fast one. The redness and swelling of the skin after squeezing blackheads is likely to be a secondary bacterial infection of the skin, and at this time you can use antibiotic ointment such as mupirocin ointment and compound polymyxin B. If there are accompanying systemic symptoms such as fever, you may need to take medication or incision and drainage to reduce the swelling. If accompanied by systemic symptoms such as fever, oral antibiotics such as cephalosporins, macrolides or tetracyclines are needed to gradually control the symptoms. If the redness and swelling are obvious, or even fluctuating sensation, consult a doctor in time for superficial ultrasound and blood tests to determine the infection before treatment, and incision and drainage can be made if there is pus. If the above situation occurs, it is recommended to go to the hospital in a timely manner, and the medication should be used according to the doctor’s prescription.