The most common sexually transmitted disease in the world is the human papillomavirus (HPV) infection of the genital, perineal and anal areas of the epidermolysis bullosa, which accounts for 25-30% of STD patients in China and hundreds of thousands of new cases each year. It is difficult to treat. In the past, ordinary laser treatment was generally used. Moreover, the treatment requires anesthesia, is painful, traumatic after treatment, slow recovery, and prone to scar stenosis. Photodynamic therapy is a new means of disease treatment based on the interaction of light, photosensitizer and oxygen. The photosensitizer Ira can be dynamically concentrated in tissues with abnormal growth (such as tumors, age-related macular lesions, macular nevus, acanthosis, etc.), and it can produce reactive oxygen species such as singlet oxygen by photodynamic reaction under the excitation of specific wavelength light, thus destroying pathological tissue cells. Ella (aminoglutarate ALA) is a precursor to the synthesis process of ferrous hemoglobin in the human body. Under normal conditions, ALA is present in small intracellular amounts and does not itself produce photosensitivity. After exogenous ALA enters the body, it is converted into strong photosensitizers such as protoporphyrin IX in cells, which generates reactive oxygen species and free radicals after illumination with specific wavelengths and energies. HPV-infected cells are actively proliferating, and the accumulated concentration of protoporphyrin IX is higher than that of surrounding normal tissues after administration, which can destroy the abnormal growth of pathological tissues with the irradiation of light waves with specific wavelengths and energies, while having less impact on surrounding normal tissues. The wart clearance rate of ALA-photodynamic therapy for condyloma acuminatum is 98.42%, but the recurrence rate is significantly lower than that of cryotherapy as well as laser treatment. In terms of safety, the incidence of adverse reactions of ALA-photodynamic therapy was significantly lower than that of cryotherapy, indicating that ALA-photodynamic therapy is safe and effective in treating warts, with a high cure rate and a low recurrence rate. It is especially suitable for perianal, intra-urethral, intracervical, and recurrent recurrent warts, and is the only therapy that can treat HPV subclinical infection and latent infection.