The worst outcomes of craniopharyngioma surgery include hypothalamic damage, impaired vision and visual field, hypopituitarism, aseptic meningitis, epilepsy, and cerebrospinal fluid leakage. 1. Hypothalamic damage: it is the most common complication after craniopharyngioma surgery, and is the main cause of postoperative death and disability. The main manifestations include uremia, temperature disorders, acute gastrointestinal bleeding, circulatory failure, overeating and obesity, cyclic loss of consciousness, etc. 2. Impaired vision and visual field: it is a common postoperative neurological deficit symptom, which is caused by intraoperative damage to the optic pathway and its supplying vessels. 3.. Hypopituitarism: especially if hypopituitarism exists preoperatively, it is usually difficult to recover. 4. Aseptic meningitis: mostly caused by intraoperative spillage of tumor capsule contents. 5. Epilepsy: it is related to factors such as cortical injury and blood sodium disorder, anti-epileptic drugs should be given to prevent it before and after operation, such as phenytoin sodium should be given, and blood sodium disorder should also be corrected. 6. Cerebrospinal fluid leakage: it is one of the complications after transsphenoidal sinus approach surgery and revealed resection of saddle node. Patients with craniopharyngioma should go to the hospital in time and standardize the treatment under the doctor’s guidance.