Patient: description of condition: husband’s physical examination revealed chronic hepatitis III, when he was treated with tibivudine for 6 months, he was fully improved: DNA turned negative from 7 times, ALT100 dropped to 24, AST50 dropped to 15. now he wants to get pregnant, we are both over 30, and I have the antibody. 1 what kind of index can my husband reach to get pregnant? 2 Is it possible to get pregnant while he is taking tibivudine? 3 If I need to stop taking the medication, how long should I take it again before stopping for a small rebound? 4 What can we do in case of rebound? How long do we have to wait again? Now it is easy for DNA to be negative. Is it safe to get pregnant on Tibivudine (Class B)? Shenyang Infectious Diseases Hospital Hepatology Department Han Yonghui: okokok : Hello! 1. Father-to-child transmission should be less likely than mother-to-child transmission, even if the hepatitis B virus carries can be considered pregnant, after all, the current newborns after the birth of the vaccination, the probability of infection is relatively low. 2. Of course, it is better if the virus does not replicate.2. It is better not to get pregnant while taking tibivudine.3. Your husband’s liver function is now back to normal, and the virus level has dropped significantly. According to Hepatitis B treatment guidelines, it is best to stop taking the medication after six months to one year of consolidation after the conversion of “major triple positive” to “minor triple positive”. In this way, there is less chance of rebound.4. In case of rebound, it is still necessary to continue the treatment.Class B drugs can only show that there is no teratogenic effect found in animal experiments, and there is no experience on whether it causes teratogenicity when people take it. You should weigh the pros and cons on your own.