Pancreatic pseudocysts that are small are almost always self-absorbed, while cysts >6 cm are less likely to be absorbed, and the sudden disappearance of a 10 cm cyst is considered to be either self-absorption or rupture of the cyst. If not combined with other discomfort, can consider the pancreatic pseudocyst self-absorption, can be clearly determined by review of abdominal ultrasound. If combined with abdominal pain, fever, bleeding, jaundice and other manifestations, it should be considered to be caused by the rupture of pancreatic pseudocysts, and then surgical treatment is required, and the common methods include pancreatic pseudocyst internal drainage, pancreatic pseudocyst resection and so on. Since the chance of self-absorption of 10 cm pancreatic pseudocyst is small, and rupture of pancreatic pseudocyst can lead to serious consequences, therefore, the disappearance of the cyst should be considered as rupture of the cyst first, and the patient should actively seek medical treatment and closely observe the changes of the condition.