The presence of symptoms but negative antigen testing generally refers to the presence of clinical symptoms associated with novel coronavirus pneumonia but negative neo-coronavirus antigen testing, and further refinement of nucleic acid testing for novel coronavirus is required in this population. It is important to note that antigen testing is used as a complementary tool for screening of specific populations, but it is not used as a clinical diagnostic criterion. The diagnostic principle of novel coronavirus pneumonia is that a comprehensive analysis based on epidemiological history, clinical manifestations, and laboratory tests is required to make a diagnosis. Therefore, people who have symptoms but negative antigen tests need not only to improve the novel coronavirus nucleic acid test to determine whether they are positive. For those who have not received the novel coronavirus vaccine, serological novel coronavirus-specific antibody testing can also be used as a reference for diagnosis. Patients with novel coronavirus pneumonia usually present with fever, malaise, and dry cough. Some patients may have symptoms such as nasal congestion, runny nose, decreased or lost sense of smell and taste, conjunctivitis, and myalgia. Therefore, if the above symptoms appear, it is recommended to improve the pathogenic, serological and chest imaging examinations promptly, which can usually confirm the diagnosis of novel coronavirus infection. If the diagnosis of novel coronavirus infection is confirmed and symptoms are present, you can cooperate with the isolation policy and receive medication such as PF-07321332/ritonavir tablets (Paxlovid), Ambavirumab/romisil monoclonal injection, Lianhua Qingfei capsule, etc., and receive oxygen therapy if necessary. It is also important to pay attention to nutritional support and ensure rest to help promote physical recovery. In cases where there is no epidemiological history, where there are symptoms but negative antigen tests, and where further laboratory tests do not reveal infection with novel coronavirus, it is also necessary to consider upper respiratory tract infections caused by other viruses, such as influenza virus, adenovirus, Mycoplasma pneumoniae, etc. This situation also requires prompt medical attention and treatment in accordance with the usual treatment measures for upper respiratory tract infections.