Portal vein cancer thrombus is effective to be treated with radio wave knife. Portal vein cancer embolism is not a separate disease, it is usually caused by the growth of liver cancer tumor to a certain degree, which invades the portal vein. Portal vein cancer thrombus not only has a high incidence rate, but also may affect the prognosis of liver cancer patients, which can be treated by interventional, radiotherapy, targeted drugs, immunotherapy and other methods. Radio-wave knife, also known as stereo-localized radio-wave surgical platform, is a new type of whole-body stereo-localized radiosurgery treatment equipment. It can treat tumors in all parts of the body, and is the only form of whole-body radiosurgery that integrates the advantages of no wound, no pain, and no bleeding. Its main indications include portal vein thrombosis, which is a more effective treatment option. As portal vein cancerous thrombus has a great impact on patients’ health, it is recommended that patients choose appropriate treatment plan under the guidance of specialists, treat it as early as possible and follow up regularly to avoid delayed treatment leading to disease progression.