Upper gastrointestinal bleeding with shock can be treated with rehydration emergency blood transfusion, fasting, medication to stop bleeding, and surgery. Once a patient is found to have upper gastrointestinal bleeding with symptoms of shock, resuscitation measures should be carried out promptly, otherwise the patient’s life safety will be affected. By promptly replenishing blood volume, anti-shock treatment, establishing intravenous infusion channels, as well as giving patients a large amount of supplementary fluids and emergency blood transfusion. The patient should also be instructed to take absolute bed rest and forbid any diet to avoid irritation to the parts of the digestive tract and to prevent the bleeding from worsening. Cardiac monitoring should be performed and oxygen should be administered continuously at low flow. The patient should be given hemostatic drugs, commonly growth inhibitors or octreotide by continuous intravenous drip. This should be combined with omeprazole injection, which can inhibit gastric acid secretion and protect the gastric mucosa. If the patient has active bleeding also requires anti-shock treatment, and if necessary, emergency gastroscopy can be performed in conjunction with a physician’s opinion in order to clarify the location of the bleeding and perform endoscopic hemostasis. If medical treatment fails, immediate consultation or surgical treatment is required.