Neonatal neuroblastoma is slightly more common in boys than in girls. Clinical manifestations of neonatal neuroblastoma are divided into two categories: symptomatic and asymptomatic: most of them have abdominal masses and adrenal masses detected by prenatal or postnatal ultrasonography, and most of them are asymptomatic, including those with masses detected by physical examination after birth. However, if the tumor is large or metastatic, corresponding symptoms will appear, often including hepatomegaly, respiratory distress, subcutaneous nodules, abdominal distention, neck mass, posterior mediastinal mass, Honer’s syndrome, fetal edema, etc. Some (10%) are combined with other malformations. Some children may progress very rapidly, such as retroperitoneal hemorrhage or spontaneous rupture of the tumor, and die within the first week of life before treatment. Neuroblastoma has been reported to be significantly associated with congenital heart disease in up to 10% to 20% of cases. Commonly, there are intracardiac structural defects, pulmonary artery malformations, and transposition of great vessels. Therefore, echocardiography should be performed after the diagnosis of neuroblastoma to observe whether the heart malformation is combined. 2. Primary tumor sites and metastatic sites are more common in the adrenal region (74.5%) and retroperitoneum (11.8%), 5.5% in the posterior mediastinum and 4.4% in the neck. Dumbbell-type compression of the spinal cord is mainly seen in the retroperitoneum and posterior mediastinum. The most common site of tumor metastasis is liver, followed by bone marrow, skin, lymph nodes, and even lung, placenta and pancreas. 3. Examination: CT scan shows that the lesions are mostly round, confined lesions, 2-5 cm in diameter, cystic, solid or mixed ∞J. Urinary VMA/HVA is only slightly elevated in half of the children and cannot be used as a basis for diagnosis; NSE and LDH are normal in more than half of the cases and have no diagnostic significance. In Korea, a group of 13 children with congenital neuroblastoma were recently reported, and bone marrow aspiration, bone scan and MIBG examination were performed only after surgical resection for pathological diagnosis, and further staging was done later. 4. ISSN staging is mainly prevalent in stage l and stage 4s. The results reported in the United States: stage 1 accounted for 42.5%, stage 2 accounted for 10.4%, stage 3 accounted for 6.2%, stage 4s accounted for 24%, stage 4 accounted for 17%; Italy reported: stage 1 accounted for 35.8%, stage 2 accounted for 11.2%, stage 3 accounted for 18.7%, stage 4s accounted for 33.6%, stage 4 accounted for 0.8% a 1. 5, the differential diagnosis should be differentiated from the following diseases: (1) adrenal hematoma; (2) cyst (3) congenital adrenocortical carcinoma; (4) adrenal adenoma; (5) subphrenic isolated lung; (6) urinary duplication malformation; (7) nephroblastoma; (8) congenital mesangial nephroma; (9) mesenteric cyst; (10) intestinal duplication malformation, etc.