Whether treatment treats tumors found early with aggressive surgery or wait and see is controversial: it has been concluded that benign processes have an overall survival rate of >95% at 4 years; small, confined lesions and a high rate of self-elimination correspond to the risk of neonatal surgery, so it is considered that this group of children does not need surgery and chemotherapy mouth. The contrary opinion is that preoperative imaging and laboratory tests cannot determine the nature of the tumor, only through surgery to obtain tissue for pathological diagnosis, and some children with tumor progression, from stage l to stage 4 or 4s, with poor prognosis mouth, should be actively treated by surgery. 1. Surgical removal of tumor is the main means to treat and cure neuroblastoma in newborns. Those with complete tumor resection do not need chemotherapy. Some children with stage 4 or 4s can also obtain long-term survival by taking biopsy only. Care should be taken to choose the timing of surgery. Neonatal surgery is safe in qualified medical centers; asymptomatic children can wait; those with symptoms need symptomatic management and even neoadjuvant chemotherapy. In particular, surgery should be performed as soon as possible to relieve the compression of spinal cord if the tumor is found to be in the spinal canal, otherwise it will cause permanent neurological symptoms. 2. Chemotherapy is mainly used for children with symptoms, such as respiratory difficulty due to enlarged liver, inability to expose the primary lesion during surgery, difficulty in closing the abdomen, and susceptibility to cavernous syndrome causing respiratory and circulatory disorders and death. The use of a 4,zytl volume VC regimen before and after surgery is aimed at improving symptoms rather than eliminating metastases. The overall prognosis of neonatal neuroblastoma is good, with an overall 5-year survival rate (OS) of 88% for children with tumors detected prenatally, compared to 64% for those detected postnatally; 5-year OS of 91% to 100% for stage 1, 93% to 96% for stage 2, 79.4% to 94.0% for stage 3, 74.1% to 79.0% for stage 4s, and 17.0% for stage 4. It is significantly better than neuroblastoma in childhood. The factors that suggest a good prognosis are H J: (1) INSS stage 1 or 2; (2) no metastasis at the initial diagnosis; (3) cystic neuroblastoma; (4) no MY-CN gene amplification; (5) DNA haploidy; (6) no chromosome l deletion; and (7) non-dumbbell-shaped tumors. children with stage 4s often have huge liver metastases and high mortality rates, which deserve concern.