The patient, a 66-year-old male, was admitted with headache with memory loss for 1 month. The cranial MRI showed bilateral frontal lobe occupations. A craniotomy was performed to remove the bifrontal lesions, and pathology confirmed glioblastoma. Postoperative radiotherapy of 60 Gy and temozolomide synchronization and adjuvant chemotherapy were administered. There were no postoperative complications. Currently progression-free survival for 14 months. The images are preoperative and postoperative axial and sagittal head MRI comparisons. The high signal (white) lesion shown by the red arrow is the tumor before surgery. The postoperative green arrow shows the operative cavity after total tumor resection (black).