A very severe and crooked looking large or small face can usually be improved clinically by surgery. However, if there is no obvious bone or tissue abnormality that is not suitable for surgical treatment, it can also be improved by exercising the chewing muscles or injecting botulinum toxin, whereas a very serious and crooked-looking large and small face caused by other diseases needs to be restored to the size of the face by treating the original disease. I. Surgical treatment: generally applicable to anatomical abnormalities resulting in a very serious and crooked-looking large and small face, the cause of the large and small face can be clarified through CT and other examinations, and the appropriate surgery can be selected according to the cause, or joint surgery can be performed in serious cases.1. Plastic surgery: for people with cranial dysplasia, which results in a very serious and crooked-looking large and small face, plastic surgery is needed to rebuild the facial bone scaffolding, such as zygomatic osteoplasty, cranioplasty and so on. After that, you can further improve the soft tissue repair on this basis; 2. Soft tissue filling: for the soft tissue development abnormality, resulting in large and small face is very serious, looks very crooked people, can be surgically filled with hyaluronic acid, autologous fat, or transplantation of prosthesis, their own fascial tissues and other methods of treatment. In addition, for people with such symptoms caused by fibrosis and spasm treatment of certain muscles in the neck, they should be corrected for strabismus first, and then operated afterward. Second, conservative treatment: more applicable to chewing habits and other acquired factors caused by one side of the muscle is more robust, and lead to the size of the face is very serious, looks very crooked. 1, chewing muscle exercise: you can consciously use the relatively small side of the face for chewing, but may be slower to take effect or the effect is not obvious; 2, botulinum toxin injections: that is, usually referred to as thinning the face of the needle, can be acted on the side of the biting muscles of the more robust, so that the biting muscles atrophy, thus alleviating the size of the face is very serious, and look very crooked. This will alleviate the seriousness of the large and small face, which looks very crooked. Third, symptomatic treatment: for the oral or maxillofacial diseases caused by the size of the face is very serious, looks very crooked, can be relieved through the treatment of the original disease. Part of the population is caused by periodontal inflammation, mumps, a tumor on one side of the face, or facial paralysis and other diseases. It may be accompanied by toothache, swelling and pain in the parotid area, lumps in the face, and crooked corners of the mouth, etc. For this kind of people, it is necessary to carry out targeted treatment for the primary disease first, such as using antibiotics, such as amoxicillin and metronidazole to treat inflammation of the mouth and parotid glands, using nutritive nerve medications, such as methylcobalamin to alleviate facial paralysis, surgical resection of lumps, etc., all of them can alleviate the situation of a very serious size of the face that looks very crooked, and if the original Recovery from primary treatment is unsatisfactory, plastic surgery, exercise of the chewing muscles and botulinum toxin injections can also be used to help improve the situation. Therefore, if there are any symptoms of facial discomfort or significant changes in shape, you should go to the hospital in time for a clear diagnosis to avoid further aggravation of large and small faces and delay in the best time for treatment.