The prognosis of hypopharyngeal cancer is poor mainly because: 1. the hypopharyngeal area is rich in lymphatic network and is prone to bilateral cervical lymph node metastasis; 2. the lesion is prone to infiltrate and spread along the mucosa or submucosa and the lesion is extensive, the actual lesion scope of the tumor often exceeds that seen in the clinical examination of the tumor, some patients’ lesions can invade the nasopharynx; 3. the hypopharynx is deeply located, the early symptoms are atypical and some of them only show sore throat. It is easy to be misdiagnosed as pharyngitis and the lesion is late when discovered; 4. The chance of hypopharyngeal cancer patients to have the second primary tumor of upper gastrointestinal tract/respiratory tract is 1/4–1/3; 5. The late stage of the lesion seriously affects the quality of life of patients, such as wasting, malignancy and immune system decline. Factors affecting the prognosis of hypopharyngeal cancer: 1, gender and age: female patients have better prognosis than male, young patients have better prognosis than old patients. 2.Tumor site: the prognosis of pear-shaped fossa cancer is better than that of posterior cricoid region and posterior pharyngeal wall region. 3.Primary tumor: the local control rate and cure rate decrease significantly with the increase of T stage. 4.Lymph node metastasis: the survival rate with lymph node metastasis is obviously lower than that without lymph node metastasis. 5.Degree of differentiation of tumor cells: tumors with low degree of differentiation have better prognosis than those with good degree of differentiation, but tumors with low degree of differentiation have higher incidence of distant metastasis than those with good degree of differentiation. 6. Treatment factors: The choice of appropriate treatment has a greater impact on the prognosis. For radiotherapy patients, the dose of radiotherapy has an impact on both local control rate and overall survival.