In patients with hypopharyngeal cancer given a routine preoperative barium swallow, it was found that a small number of patients have combined esophageal cancer often involving the upper middle or even lower segments. OBJECTIVE: To investigate the treatment modality, value and characteristics of hypopharyngeal cancer combined with esophageal cancer. METHODS: Gastropharyngeal anastomosis was performed for patients with no contraindications to surgery by performing hypopharyngeal stripping and lifting the stomach instead of the hypopharynx of the esophagus. The clinical data of 11 patients with hypopharyngeal cancer combined with esophageal cancer were analyzed regressively to analyze their clinical characteristics, surgical indications, and complications. Their prognosis was analyzed using survival curves. RESULTS: Six of the 11 cases underwent surgery, and one of them underwent gastric pyloric-jejunostomy with open duodenum and then gastric supersession for esophageal hypopharynx because the direct gastric supersession was not long enough, and after loosening the gastric lesser curvature was still not long enough. 5 patients refused surgery, and all patients died within 8 months after diagnosis. 11 cases of combined esophageal cancer included 4 cases of upper esophageal cancer, 5 cases of middle esophageal cancer, and 2 cases of lower esophageal cancer. The cumulative recurrence rates of the six operated patients were 50.0% and 66.7% at one year and three years, and the survival rates were 50.0% and 33.3% at one year and three years, respectively. Surgical complications included 2 cases of pharyngeal fistula, 1 case of intestinal obstruction, and 1 case of intestinal fistula, etc. There were no deaths during hospitalization, and the average number of hospital days was 26 days. All four patients without complications maintained albumin and globulin in the normal range, and applied two gastric tubes for decompression drainage and isoamyl ether hydrochloride intramuscularly to reduce pharyngeal secretions. Patients with pharyngeal fistulae all had hypoproteinemia and a large amount of gastric fluid drainage out. Conclusion: Patients with surgical opportunities can prolong their survival by receiving a comprehensive treatment based on surgical treatment, and gastric uplift instead of esophageal hypopharynx is a more ideal surgical procedure for hypopharyngeal cancer combined with esophageal cancer. Postoperatively, it is important to maintain the patient’s nutrition to improve hypoproteinemia, reduce secretions at the anastomosis, and maintain water-electrolyte balance to prevent pharyngeal fistula.