With the popularization of testing methods, the detection rate of positive mycoplasma has increased significantly. Due to the little understanding of mycoplasma, many patients are troubled by mycoplasma positivity and suffer from great mental stress, and how they should deal with mycoplasma positivity has become a growing concern for this group of people. Mycoplasma is a simple prokaryotic organism, there are about a dozen types of mycoplasma that infect humans, and the main ones that are closely related to genitourinary tract diseases are Mycoplasma solium and Mycoplasma mansoni. Others are Mycoplasma genitalium and Mycoplasma pneumoniae. Mycoplasma urealyticum, as one of the normal vaginal flora, also has a high rate of carriage in the healthy population, i.e. it coexists with the host without showing symptoms of infection, but only causes infection under certain conditions or mixed infection with other pathogenic bacteria. Therefore, the pathogenicity of Mycoplasma solani and the need for treatment are still controversial in medical science. In contrast, human mycoplasma is thought to have a correlation with vaginitis, cervicitis, and tubal infections. However, mycoplasma infections of the genital tract usually have no obvious clinical symptoms, and those that do are mostly vaginitis and cervicitis with increased vaginal discharge or purulent discharge, and pelvic inflammatory symptoms are often mild. For mycoplasma genitalium positivity during pregnancy, some research data suggest that Mycoplasma solani is associated with adverse pregnancy outcomes such as premature rupture of membranes and preterm delivery, but most clinical research data suggest that detection of Mycoplasma solani in the lower genital tract during pregnancy does not increase adverse pregnancy outcomes. Therefore, for those who are positive for Mycoplasma urealyticum without symptoms and signs, especially those who have already given birth, no treatment can be chosen; for those who are positive for Mycoplasma urealyticum with symptoms and signs of vaginitis and cervicitis, but no other pathogenic factors are found, especially those who have not yet given birth, treatment can be given, and azithromycin, clindamycin or quinolones are still preferred; and for those who are positive for Mycoplasma urealyticum in the lower genital tract during pregnancy, whether to carry out The decision of whether to intervene and treat Mycoplasma solani detected in the lower genital tract during pregnancy can be based on the specific situation of the patient, and erythromycin can be preferred for those who need treatment.