1, women: many people, especially middle-aged women, tend to stay at home more time, exercise and physical labor less, the contraction force of their gallbladder muscle is bound to decline over time, bile emptying delayed, easy to cause bile stasis, cholesterol crystal precipitation, creating the conditions for the formation of cholelithiasis. In addition, the high level of estrogen in women affects the formation of glucuronide bilirubin in the liver and increases unconjugated bilirubin, while estrogen affects gallbladder emptying, causing bile stagnation and promoting stone formation. Those who take estrogen for postmenopausal syndrome have a significantly higher prevalence of gallstone disease. 2, the elderly: according to statistics. The older you are, the greater the chance of gallstone disease. This is because the elderly are less active, the diet is relatively reduced, the gallbladder contraction force is weakened, bile stagnation formation of stones. 3, obese people: research shows that people whose weight exceeds 15% of the normal standard, the prevalence of gallstone disease is 5 times higher than normal people. This is because obese people have elevated blood cholesterol, so that the concentration of cholesterol in the bile is also elevated, thus prone to the formation of cholesterol stones. 4, long-term skipped breakfast: medical experts on women suffering from gallstone disease with some of their age, weight similar to the healthy women did a control survey, the results found that these women suffering from gallstone disease fasting time are longer than healthy women. The reason for this is that bile secretion decreases during fasting, and the composition of bile also changes, which reduces the bile content and causes cholesterol to be deposited in the gallbladder. In the long run, cholesterol stones can be formed. 5, love to eat greasy, sweet food: medical experts have found in a sample survey, more than 90% of gallstone patients have the habit of eating sweet food. Excess sugar will increase insulin secretion, accelerating the accumulation of cholesterol, and will also be converted into fat by itself, prompting the body to gain weight, which in turn causes increased cholesterol secretion, thus contributing to the occurrence of gallstone disease. Preference for meat, greasy and sweet food is an important cause of gallstones. The intake of a large amount of fatty food is bound to increase the fat and cholesterol content in body fluids, making it easy to form cholesterol stones. 6, long-term vegetarians: too much fat in the diet, cholesterol is too high, although the formation of gallstone, but the normal cholesterol and bile salts, phosphatidylcholine in a certain proportion of the mixture is a micro-colloid state suspended in the bile, when this ratio is disrupted, can cause gallstone disease. Long-term vegetarians do not consume enough phosphatidylcholine, and too much fiber in the vegetarian diet prevents the reabsorption of bile acids and reduces the concentration of bile salts in the bile, and phosphatidylcholine is not enough for bile salts, resulting in an imbalance in the ratio, causing gallstone disease. 7, roundworm infection: do not pay attention to dietary hygiene, it is easy to swallow roundworm eggs into the digestive tract, develop into adult worms and reflux into the bile ducts to lay eggs or die, which can form gallstone core. According to the survey, the high prevalence area of gallstone disease in China, 70% of gallstone disease is the core of roundworm residue or roundworm eggs. 8, multiple pregnancies: According to statistics, 70% of gallstone patients are women, and it is proportional to the number of pregnancies. Because women during pregnancy bile duct function is prone to disorders, resulting in smooth muscle contraction weakness, so that the gallbladder bile retention, coupled with the relative increase in blood cholesterol during pregnancy, prone to precipitation, the chances of forming gallstone disease is greatly increased. 9, after-dinner snacks: Now many families in China can see the situation, the family after dinner, sitting leisurely on the sofa, while eating snacks while chatting and watching TV. This habit of sitting and eating snacks after meals may be one of the reasons for the gradual increase in the prevalence of gallstone disease in China. When a person is in a curled position, the intra-abdominal pressure increases, the gastrointestinal tract peristalsis is restricted, which is not conducive to the digestion and absorption of food and bile excretion, sitting after a meal prevents the reabsorption of bile acids, resulting in an imbalance in the ratio of cholesterol to bile acids in bile, cholesterol is easy to deposit. 10, cirrhosis of the liver: this is related to the lowering of estrogen inactivation function in patients with cirrhosis of the liver, the body of estrogen inactivation function is low, the estrogen level is higher, coupled with cirrhosis of the liver so that the gallbladder contraction function is low, poor emptying of the gallbladder, bile duct varices, elevated bilirubin in the blood and other factors can cause gallstone. 11, like static less active: some middle-aged and elderly people tend to like static less active, lack of exercise, the body is easy to fat, cholesterol metabolism disorder, so that bile stagnation, the formation of stones. Some people sit on the sofa after meals or eat while watching TV, which affects the digestion and absorption of food, which is not conducive to bile excretion, and cholesterol is easily deposited into stones. 12.Patients with certain diseases: (1) hemolytic anemia. 1/2~1/3 of them suffer from bile pigment stones, which is due to the release of large amount of hemoglobin from hemolysis, and more bilirubin in the blood after hemoglobin decomposition. (2) Diabetes, cirrhosis of the liver, hyperthyroidism. These patients are prone to gallstones, which may be related to the reduced synthesis and elimination of bile salts in the bile. (3) Small bowel disease or small bowel ostomy, vagotomy for duodenal ulcer disease. These patients are prone to gallstones, which may be related to the disturbance of bile salt metabolism and the difficulty of bile evacuation from the gallbladder after surgery. (4) Gallbladder cancer, pancreatitis, allergic colitis, ulcerative colonic restrictive enteritis and other diseases. Some of these patients will develop gallstones, and the higher percentage of them are gallbladder cancer (70% to 80% have gallstones) and pancreatitis (about 30% have gallstones in combination). (5) Patients after gastrectomy. The surgery cuts the nerve that controls the movement of gallbladder, which reduces the function of gallbladder movement, so they are prone to gallstones. 13. Genetic factors: Genetic factors apparently play an important role in defining the risk of gallstone disease, which is more frequently produced in close relatives of patients with cholesterol gallstones. The fact that natives of the southwestern United States have a high risk of cholesterol gallstone disease (more than 80%) seems to include a genetic factor.