A plaque filling defect is a condition in which imaging is performed and it is found that there is no contrast in a particular area during development. During imaging, a contrast medium is used to help visualize the condition of the blood vessel, and the presence of plaque at a particular location causes the lumen of the vessel to be partially occupied, narrowing the flow of the contrast medium, i.e., the plaque in the vessel is not filling with contrast medium. This usually indicates that there is a plaque in the blood vessel that occupies the lumen of the blood vessel, which is commonly seen in carotid artery atherosclerosis. The reason for its formation may be unhealthy diet, long-term consumption of greasy food, and may lack of exercise, resulting in elevated blood lipids, and the gradual formation of plaque. At this point, the doctor will help the patient choose the appropriate treatment according to the situation, and can take lipid-lowering drugs, such as simvastatin and pitavastatin. At the same time with the addition of aspirin and other anti-platelet aggregation drugs, it is recommended that symptoms or checkups appear in a timely manner to seek medical treatment to avoid aggravation of the condition.