The main treatment modalities for ulcerative colitis relapse with discharge of pus and blood stool include adjusting lifestyle habits, medication such as mesalazine and azathioprine, and surgical treatment. The main symptoms of ulcerative colitis are recurrent abdominal pain, diarrhea, discharge of pus and blood stools, etc. Regular treatment can control the condition and achieve remission, and the main treatment modalities in case of recurrence include the following. 1. Adjustment of living habits: regular work and rest, avoiding hard work and staying up late; adjusting the diet structure, avoiding indigestible food and stimulating food. 2. Drug treatment: Amino salicylic acid preparations such as mesalazine can be preferred to relieve symptoms; if the treatment of amino salicylic acid preparations is ineffective, especially if the lesions are extensive, glucocorticoid drugs such as prednisone can be used to improve the symptoms; if the hormone dependence or the symptoms are difficult to be relieved, immunosuppressant agents such as azathioprine and biologics such as infliximab can be added to the comprehensive treatment. 3. Surgery: If the symptoms of pus and blood in the stool continue to be difficult to relieve or there are serious complications such as perforation, the treatment can be carried out through intestinal segmental resection. The discharge of pus and blood stools after the recurrence of ulcerative colitis requires regular treatment in a regular hospital to avoid further development of the disease, leading to serious consequences.