If a patient with a clear diagnosis of prostate cancer has a chance for surgery, do not give up easily. In the following, I will talk about a recent case of a patient with late clinical stage prostate cancer.1 A 52-year-old man was admitted to the hospital for 4 months because of slight difficulty in urination. He was found to have a hard, nodular prostate of degree III with difficulty in pushing the anterior rectal wall. 54 ng/ml of PSA and a rectal prostate puncture biopsy reported: adenocarcinoma of the prostate with a Gleason score of 8 (4+4).2 The pre-biopsy MRI suggested that there were low signal masses in the right and left lobes of the prostate, and the right posterior lobe of the prostate invaded the anterior rectal wall. Chen Fangmin, Department of Urology, Affiliated Hospital of Guizhou Medical University.3 Bone scan results: no significant bone dense imaging was seen throughout the body. Clinical diagnosis: prostate cancer (T4N0M0) very high risk type4 Because of the relatively young age of the patient, the family and the patient strongly requested surgical treatment and expressed understanding for the outcome that occurred in the perioperative period. After careful review of the patient’s data and imaging results and adequate preparation, laparoscopic radical prostate cancer surgery was performed. Intraoperatively, as shown in the imaging data, the prostate lesion was tightly adherent to the right posterior lobe of the rectum, and the prostate was routinely excised, 9 lymphs were cleared, and the right posterior lobe lesion was excised as much as possible (under the premise of avoiding damage to the rectum), with a small portion remaining, and the urethra was anastomosed with the bladder neck set. The postoperative pathology report: prostate adenocarcinoma, Gleason score 9 (4+5), lymph nodes left 4 (negative), right 4 (negative).5 Three weeks after surgery, the urinary catheter was removed, PSA 4.08ng/ml. six months after surgery, the review, mental diet are normal, excellent condition, blood TPSA 4.12ng/ml. urination is normal, urinary control is very good. The patient was advised to continue local pelvic radiotherapy and drug depot treatment, with follow-up in progress. So, my opinion is: the diagnosis of prostate cancer is clear, as long as there is no bone metastasis or metastasis from other sites. Surgical treatment can be performed to improve the symptoms and improve the quality of life.