Methicillin-resistant Staphylococcus aureus is treated with vancomycin antibiotics, including vancomycin, desmethylvancomycin, and teicoplanin, and the oxazolidinone linezolid can also treat sepsis, endocarditis, osteomyelitis, and respiratory tract infections caused by methicillin-resistant Staphylococcus aureus. Vancomycin and teicoplanin are widely distributed in the body after entering the body, and the vast majority of them are excreted in the form of urine through the kidneys. The main adverse effect is ototoxicity, and patients may experience tinnitus, hearing loss or even deafness, and the symptoms can be relieved by stopping the drug. In addition, it can cause kidney damage, and patients can develop hematuria, proteinuria and even renal failure; in rare cases, skin rash and anaphylaxis can occur; other patients can develop gastrointestinal symptoms such as nausea and vomiting. In contrast, linezolid has less kidney damage, but long-term application can cause side effects such as lower platelets and lower white blood cells in the blood system.