Patients with anal fissures can use potassium permanganate. Clinically, for patients whose anal fissures are not very serious, early fresh anal fissures can be treated with potassium permanganate sitz baths, which can be made with a 1:5000 solution of potassium permanganate to promote wound healing. However, the use of potassium permanganate alone cannot solve the problem of anal fissure itself for severe fissures and cannot achieve a very effective treatment effect. Patients should use nitroglycerin or diltiazem topically, and some can also use erythromycin ointment or Ma Yinglong hemorrhoid cream, together with the use of anal pessary or Ma Yinglong hemorrhoid suppository comprehensive treatment. So the treatment for anal fissures depends on the severity of the fissure itself. Early mild fissures can be treated with potassium permanganate alone, while more serious fissures should be treated with topical medication. Some recurrent attacks form old anal fissures, and when conservative treatment is not effective, surgical treatment is needed.