Splenic pain usually presents as an acute dull or persistent colicky pain in the left upper abdomen that can radiate to the left shoulder or back, accompanied by nausea, vomiting, and loss of appetite. 1. Splenic pain can be caused by splenic artery embolism, resulting in ischemic pain and severe pain in the spleen; severe traumatic stimulation, resulting in rupture of the spleen, can also lead to splenic pain. 2. Cirrhosis, hematological diseases, splenic tumors and other splenic enlargement lead to increased pressure on the splenic pericardium, and the patient will experience splenic pain, which is mostly a persistent colicky pain. 3. In case of hypersplenism, patients will have splenomegaly and hematopoiesis, etc., which may be combined with cirrhosis and other diseases, and may occasionally be accompanied by infections, and the treatment may include the use of adrenaline and glucocorticosteroids, etc. as prescribed by the doctor. Patients should pay attention to regular daily routine, appropriate exercise to enhance the body’s immunity. In addition, patients with splenic pain should actively seek medical attention to clarify the cause of the disease and follow the doctor’s instructions to standardize the treatment.