Prostate cancer is the most common malignancy of the male genitourinary system. Epidemiological studies have shown that the occurrence of prostate cancer is mainly related to factors such as age, race, family genetic background, geographic location and dietary structure. Worldwide, prostate cancer is the second most common malignancy in men, second only to lung cancer. Compared to developed countries, China is a low incidence country for prostate cancer, but the incidence rate has been increasing year by year in the last decade. The main reason for this is generally believed to be related to the widespread use of prostate-specific antigen (PSA) for tumor screening and the increased level of early prostate cancer diagnosis. Prostate cancer has no specific symptoms, no discomfort in the early stage. When the tumor increases to a certain size, it may cause urinary frequency, urinary urgency, difficulty in urination, and in a few cases, hematuria, which is exactly the same as the clinical manifestation of benign prostatic hypertrophy! When the tumor compresses or invades the surrounding lymph and blood vessels, lower limb edema appears, or bone metastasis occurs and bone pain is felt when it is too late – the chance of radical cure is lost. Radical prostate cancer surgery is already a very mature technology, the key is how to detect it early The answer is screening. Currently, the outpatient screening methods for prostate cancer are simple: 1 physical examination – rectal finger examination, 2 blood sampling – prostate specific antigen (PSA), 3 imaging – transrectal ultrasound scan. Anal finger examination Ultrasound guided prostate puncture Based on our own clinical findings that prostate cancer is mostly advanced, although we have seen prostate cancer patients as young as 26 years old, the vast majority of patients are over 45 years old, therefore we recommend that men over 45 years old should be screened for prostate cancer at least once a year. Once prostate cancer is suspected, don’t hesitate to start preparing for a very minor procedure – a prostate puncture biopsy is the gold standard for confirming prostate cancer. The puncture can be performed either transrectally or perineally, usually under ultrasound guidance. Prostate puncture is required in the following cases: ①Nodules found on rectal examination ②PSA >10ng/ml or PSA 4-10ng/ml with f/tPSA ratio less than 0.16 ③Prostate hypoechoic nodules found on ultrasound A preoperative MRI diffusion imaging can help improve the positive rate of puncture. The ultrasound-guided saturation puncture method with more than 19 stitches: it greatly improves the positive rate of small prostate tumor puncture and reduces the leakage rate to very low. For prostate cancer that has lost the chance of radical treatment, endocrine therapy, local radiotherapy or cryoablation, chemotherapy and bioimmunotherapy can be chosen. Although the results are better than other urological tumors, the current 5-year survival rate is still only 48.8%, which means that more than half of the people may pass away within 5 years! Early screening, early treatment and early surgery of prostate cancer is the key to cure. We should raise our awareness of cancer prevention and fight against cancer, not only do we not need to talk about cancer and worry about it, but also do not be careless and miss the disease.