Diabetic foot is a serious complication of diabetes mellitus with a high rate of disability and death due to foot infections, ulcers and deep tissue destruction caused by arteriopathy and local nerve abnormalities in the lower extremities caused by diabetes mellitus. Lower extremity arterial occlusive disease is the main cause of the development and deterioration of diabetic foot, often manifested as intermittent claudication, lower extremity pain, cold extremities, diminished or absent dorsalis pedis artery pulsation, foot ulceration or gangrene, etc. Vascular occlusions are classified into incomplete and complete occlusions according to the degree of occlusion, and segmental and extensive occlusions according to the extent of occlusion. The booming development of vascular interventions has brought a new light to diabetic foot patients. Lower extremity interventional treatment of diabetic foot is a new technology just starting in China, which is performed by doctors from vascular surgery, interventional department and endocrinology in cooperation with each other. The purpose of endovascular intervention is to open the occluded blood vessels, save the ischemic lower limbs, reduce the amputation rate and improve the quality of life of diabetic foot patients. The procedures include percutaneous transluminal angioplasty (PTA), endovascular stent placement, transcatheter intra-arterial thrombolysis, ultrasound ablation, atheromatous plaque fast spinotomy, and percutaneous mechanical thrombus ablation. PTA is one of the most advanced techniques in the treatment of diabetic foot internationally. It is performed by compressing the atheromatous plaque through a pressurized balloon, which causes the plaque shell to rupture under pressure and dilate the lumen; in addition, the lumen is enlarged by overstretching the elastic fibers, collagen fibers and smooth muscle cells in the middle layer of the artery. After lumen expansion, the lumen is usually not easily restenosed due to enhanced pulsatile blood flow. During the procedure, we use the interventional technique of contrast to perform a conventional contrast through retrograde or paralleling puncture and cannulation of the contralateral or ipsilateral femoral artery to clarify the lesion site, the degree of occlusion, and the collateral circulation, and place a balloon at the stenosis site under the guidance of a guidewire according to the actual situation. If the stenosis is unsatisfactory, a suitable endoluminal stent is placed, followed by anticoagulation therapy and drugs to improve microvascular circulation, which can effectively treat diabetic foot caused by severe stenosis or occlusion of lower limb vessels. PTA is suitable for segmental stenotic lesions, as extensive stenosis and occlusive lesions are prone to vascular injury due to multiple segmental dilatation with balloon catheters. Compared with surgical procedures, this treatment method has outstanding advantages such as less trauma, exact efficacy, fast results, simple operation, less complications, and reproducibility. The main problem facing the use of interventional methods is the restenosis of diseased vessels. The causes are mainly technical defects, too low recanalization blood flow or increased blood coagulation in the early stage, intimal hyperplasia in the recanalized vessels in the middle stage, and continued development of atherosclerosis in the late stage. However, due to the reproducibility of this method, it is no less ideal for the treatment of diabetic foot.