Diabetic foot is one of the three major complications of advanced diabetes mellitus, with a high rate of disability and death, seriously affecting the health of patients and the quality of life, and is also a very difficult foot syndrome in clinical practice. Diabetic foot is a group of foot syndrome, not a single symptom, it should have several elements: first, diabetic patients; second, there should be a manifestation of dystrophy of foot tissue (ulcer or gangrene); third, accompanied by certain lower limb nerve and/or vascular lesions, one of the three cannot be missing. A foreign research group has shown in an 8-year multicenter prospective study of 1107 patients with diabetic lower extremity ischemia that the final outcome was ulceration, amputation or death. Early and effective treatment determines the prognosis, therefore, it is important to provide early education to the majority of diabetic patients and to pay great attention to the prevention of this syndrome. The pathogenesis of diabetic foot is mainly due to the disturbance of sugar and lipid metabolism in the patient’s body, on the basis of which plaque is deposited on the arterial wall and gradually calcifies, which leads to the narrowing or even occlusion of the arterial lumen, causing ischemia and hypoxia in the distal tissues of the lower limbs, malnutrition, and eventually tissue loss. The epidemiological survey in the United States found that the main reason for hospitalization of diabetic patients is diabetic foot, foot ulcers mostly occur 10 years after the onset of diabetes, and the incidence of diabetic foot will reach 50% in patients with more than 20 years of disease. In recent years, China has investigated the proportion of lower limb arteriopathy in people over 50 years of age with diabetes is 19.47%. 90.8% of type 2 diabetic lower limb vasculopathy occurs, of which 43.3% is severe or more. The number of diabetic foot patients is increasing rapidly in recent years, which should be paid great attention to. There are three types of diabetic foot, namely ischemic, neurologic and neuroischemic, and their clinical manifestations are different. The most common type of diabetic foot in China is the neuroischemic type, which is the mixed type. At present, there is no effective treatment for neurological lesions, while for the other two types, most patients can achieve certain results by rebuilding blood flow in the lower limbs. In the past, the treatment of diabetic foot was mainly based on medication and surgical debridement, but because the important cause of foot ulcers —- lower limb vascular stenosis and occlusion was not solved, often “treating the symptoms but not the root cause”, the efficacy was not satisfactory. With the continuous development of medical level, the treatment of diabetic foot, especially ischemic patients, has a new concept and method. It can be dealt with by the method of “internal” and “external” treatment. The “internal” approach is to open the occluded arteries of the lower extremities, i.e., to start from the source of the ulcer, open the narrowed and occluded arteries through intracavitary techniques and instruments, improve the blood supply to the foot, enhance the local resistance to infection, and thus promote the growth of the wound. Current endoluminal techniques and devices are advancing rapidly, and most traditional major invasive procedures have been replaced by minimally invasive endoluminal vascular techniques. Using this technique only requires puncture through the upper extremity (brachial artery) or groin (femoral artery), using special tools to open the diseased vessel and perform plaque spinning, stent implantation, and balloon dilation, if necessary, to achieve treatment. This method is less invasive, has a quick recovery, is highly reproducible, has a low complication rate, and is particularly useful for some elderly patients who cannot tolerate traditional surgery. Of course, simple vascular opening is not enough, for infected wounds, a thorough debridement treatment should be performed —- “outside” the wound. Appropriate application of antimicrobial drugs, cleaning of necrotic tissues, topical ointments, and enhanced wound management are all very important components of treatment. Of course, we must also be aware that although some diabetic foot can be treated, the most critical relief is prevention. Patients need to pay great attention to this disease, from active control of underlying diseases, reasonable diet, quit bad habits, pay attention to foot hygiene, reduce the chance of foot breakdown, pay attention to warmth and other aspects, to stay away from the threat of diabetic foot. Once the symptoms appear, you should undergo vascular examination as soon as possible and receive early diagnosis and scientific and standardized comprehensive treatment. It is important to protect your feet and limbs!