Diabetic foot is an infection, ulcer and/or deep tissue destruction of the foot diaphragm (ankle or part below the ankle joint) associated with diabetic distal nerve abnormalities and varying degrees of peripheral vascular disease in the lower extremity. With the development of economy and the change of people’s lifestyle, the prevalence of diabetes has increased dramatically and the incidence of diabetic foot has gradually increased, which has become the main cause of non-traumatic amputation. Diabetic foot not only makes the quality of life of patients seriously reduced, but also makes treatment quite difficult, with long treatment period and high medical cost, which brings heavy burden to patients and society. One of the main causes of diabetic foot is the arteriosclerosis and intimal thickening of the lower limbs caused by diabetes, resulting in lumen narrowing or even occlusion, causing ischemia and hypoxia in the distal part of the lower limbs, especially the foot. Interventional treatment of diabetic lower extremity vasculopathy can effectively and quickly restore blood flow to the foot, and has immediate effects, making it the treatment of choice for an increasing number of diabetic foot patients. The traditional medical treatment for diabetic foot mainly includes active blood sugar control, vasodilation, nerve nutrition, wound dressing and systemic antibiotics, etc. However, the treatment effect is unsatisfactory because it does not fundamentally solve the blood flow problem, and the treatment time is long and costly. Most of the surgical procedures are difficult to deal with these extensive lesions, and most of the patients are old and frail, often have cardiovascular and cerebrovascular complications, and are unable to tolerate the trauma caused by surgery. Vascular intervention requires only local anesthesia, arterial puncture, and operation by guidewire catheter, which has the advantages of less bleeding, less trauma, less complications, safety and reliability, and faster postoperative recovery, etc. It greatly reduces the pain of patients, decreases the difficulty of operation for the surgeon, fast postoperative recovery, short hospitalization time, and is easy to repeat. It has obvious advantages for patients who are old and frail, have more comorbidities, cannot tolerate vascular bypass or have contraindications to surgery. With the advancement of interventional techniques and products, there is an increasing number of studies on the application of interventional therapy to diabetic lower extremity vasculopathy. The results showed that angioplasty was not only safe but also simple compared to open surgery, but the closer the foot lesion was to the distal end, the effect of endovascular intervention was reduced accordingly. Faglia et al. achieved satisfactory clinical results by performing PTA of the infrapopliteal artery in 993 patients with severe limb ischemia and diabetes mellitus, and concluded that balloon dilatation angioplasty should be preferred for revascularization of diabetic lower extremity vascular lesions. Studies have shown that balloon dilation is an effective method for limb preservation in diabetic patients with severe limb ischemia caused by lesions below the carotid artery, and stenting of the infrapopliteal artery has also been gradually applied in recent years, with a high success rate of infrapopliteal balloon dilation with stent implantation and few complications, which can be applied to patients of advanced age with multiple comorbidities. The large set of studies proved that interventional treatment of diabetic lower extremity vasculopathy is safe and effective compared with surgical blood flow reconstruction, with significant improvement in clinical symptoms, avoidance of amputation or reduction of amputation plane, and salvage of foot function, with significant recent efficacy. The main goal of infrapopliteal artery intervention is to obtain direct blood flow to the foot; its clinical objectives are to promote ulcer healing, reduce pain, and avoid amputation to the greatest extent possible. These are the main goals of angioplasty, and it is not necessary to ensure long-term patency of the patient’s vasculature after a single intervention. For diabetic foot sub-knee vasculopathy, balloon dilation treatment can rapidly improve the blood supply to the limb. The restenosis after balloon dilation is a gradual process, with the gradual formation of restenosis, the lateral branch circulation of the limb is also compensated and established, which is the clinical significance and value of balloon dilation treatment, and is the key point that the limb saving rate is much higher than the vascular patency rate; balloon dilation is repeatable, for restenotic lesions can be dilated again, even if the procedure fails Even if the procedure fails, it will not prevent further vascular bypass grafting.