Patients with multiple myeloma and their families are very concerned about the trend of the disease. What are the main relevant evaluation indicators?1. M protein identification, which is indisputable and not explained separately. Hint: The quantitative determination of urine light chain must be checked in 24-hour urine, random urine light chain quantification is not significant. 2. bone marrow aspiration, because of the heterogeneity of plasma cell distribution, it is recommended to check different sites, in addition, it is unnecessary to check bone aspiration before each chemotherapy. This index is not as important as M protein, but bone aspiration is necessary to evaluate whether the disease is in complete remission.3. Blood count. Especially in patients with previous hypotension.4. Serum and urinary beta2 microglobulin. This indicator indirectly reflects the tumor load in the body. 5. Erythrocyte sedimentation rate. This indicator correlates with the disease, but is not specific.7. Blood biochemistry. Pay attention to liver and kidney function, LDH, uric acid, etc.8. C-reactive protein. This is also correlated with the disease, but is affected by a variety of factors.9. BNP (this must be checked if preexisting cardiac involvement is suspected).10. Imaging, such as X-rays, MRI, or CT, and PET-CT if necessary, which is primarily to assess for new skeletal lesions, or extramedullary plasmacytomas.11. ECG (especially in patients with multiple chemotherapy, the heart must be noted).12. 4. Hourly urine total microprotein. This is quite important for the evaluation of patients with combined myeloma nephropathy.13. Abdominal ultrasound if necessary. This is primarily a primary screen for patients suspected of having intra-abdominal invasion of the primary disease.14, Serum free light chain. This is mainly for patients who have achieved complete remission. The above is for the reference of outpatient follow-up patients.