Acute appendicitis is a common pediatric surgical disease that can occur in children of all ages, and treatment is divided into surgical and conservative treatment, which requires the application of antibiotics regardless of surgical or conservative treatment. The causative agent of appendicitis in children is mostly Escherichia coli, and the sensitive antibiotics for this type of bacteria are usually penicillins, such as piperacillin sodium tazobactam, meloxicillin sodium sulbactam sodium, amoxicillin, etc. There are also cephalosporin antibiotics, such as ceftriaxone sodium, cefoperazone sodium sulbactam sodium, etc. Since the appendix is connected to the intestinal canal of the cecum and there are a large number of anaerobic bacteria in the intestinal tract, it is recommended to combine anti-anaerobic drugs like metronidazole or tinidazole for a more ideal treatment of appendicitis. If the disease progresses quickly and the inflammation is not well controlled, it is still recommended to operate as soon as possible, and to take the peritoneal exudate for bacterial culture plus drug sensitivity during the operation, and to choose sensitive antibiotics for treatment according to the drug sensitivity results.