When acute appendicitis occurs in the middle of the night, you should first go to the hospital for detailed consultation. If the symptoms of infection are severe, and the percentage of routine blood leukocytes and neutrophils is significantly higher, in this case surgery should be selected as an emergency treatment to remove the primary lesion, and postoperative supportive treatment such as anti-infection and intravenous rehydration should also be administered systematically. In case of acute simple appendicitis with mild symptoms and signs, conservative treatment can also be chosen, including anti-infection, water fasting, intravenous fluid supplementation, replenishment of the body’s basic needs of sugars and trace elements and various ions, as well as monitoring of the blood routine and changes in the internal environment to prevent ionic disturbances and acid-base imbalance. If the symptoms gradually improve, it means that the conservative treatment is effective, and if it gradually worsens, it is also necessary to choose surgical treatment.