The effectiveness of cyclophosphamide in the treatment of nephropathy is determined clinically according to the specific type of pathology. In most cases, cyclophosphamide can be added if hormones alone do not work well, which can prevent recurrence of the disease and has a good prognosis for the disease. For example, in microscopic lesion type, most of them can be cured by hormone alone, but adding cyclophosphamide can prevent recurrence. For membranous nephropathy, most of the hormones alone are ineffective and need to be treated with cyclophosphamide, which is recommended to be used once a month with a cumulative effect of 6-8g, but it is recommended to review the blood routine, liver function and ionized kidney function before each use. Some pathological types, such as thylakoid proliferative glomerulonephritis, thylakoid capillary glomerulonephritis, and focal segmental sclerosing glomerulonephritis, are less effective with cyclophosphamide and will not result in clinical cure.