Physical therapy such as microwave, electrocautery, and laser may be used if cryotherapy for pyogenic granuloma does not work. Surgical excision should be used for patients with more extensive skin damage. The patient can choose the appropriate treatment plan under the advice of the doctor. Pyogenic granuloma, also known as lobulated capillary tumor, is a benign acquired proliferative capillary tumor that occurs mainly in the skin and mucous membranes. When cryotherapy is ineffective, the following common options are also available: 1. Smaller granulomas and some pyogenic granulomas of pregnancy may resolve on their own without treatment. 2. Larger pyogenic granulomas are treated with surgical excision, while other treatments include laser, electrocoagulation, liquid nitrogen freezing, and topical medications (e.g., imiquimod cream, retinoic acid gel, etc.). Pyogenic granuloma cryotherapy has no effect can be under the guidance of the doctor’s advice to choose the above methods of treatment. For patients with relatively large skin damage, surgical excision should be performed as soon as possible.