The development of sebaceous glands is directly influenced by sex hormones. When the androgen level in the body increases, it can promote the development of sebaceous glands on the skin and produce a large amount of sebum, which can easily induce the formation of acne and other skin diseases. Spironolactone has an anti-androgen effect, which can reduce the level of androgens in the body and inhibit the secretion of sebaceous glands, thus alleviating acne and other skin diseases and making the skin better. As an aldosterone receptor antagonist, spironolactone is often used clinically as a traditional diuretic drug. However, spironolactone can inhibit the production of androgens in the gonads by blocking cytochromes and can compete with androgens in the body to bind to androgen receptors on the skin, effectively inhibiting the secretion of sebum and the accumulation of sebum on the local skin, which can reduce the size of sebum plugs in acne such as whiteheads and blackheads and facilitate the fading of skin damage in the affected area. Therefore, in some cases, it can also be used in the treatment of female acne, which can significantly help to improve the skin. It is important to note that when spironolactone is used to treat skin-related conditions such as acne, it should not be used in large amounts for long periods of time. Also, some patients may experience gastrointestinal symptoms such as nausea, vomiting, abdominal pain, diarrhea, etc., as well as headache, dizziness, fever, and skin rash after spironolactone application. Due to its anti-androgenic effect, spironolactone can also cause breast enlargement and sexual dysfunction in men when used in excess. It is recommended to use it under the guidance of a doctor, and not to use it privately. If the above-mentioned uncomfortable symptoms occur during taking the drug, it is recommended to communicate with the doctor in time, and the doctor will give relevant medication guidance after comprehensive assessment.