Hepatitis B virus (HBV) infection is an important cause of chronic hepatitis, liver cirrhosis and liver cancer. There are 120 million HBV carriers in China; at this stage, the HBV infection rate among people of childbearing age is still as high as 8.16%. Interruption of mother-to-child transmission of hepatitis B virus is the key to comprehensive control of the hepatitis B virus epidemic, and the 2010 Chinese guidelines for the prevention and treatment of hepatitis B state that “antiviral therapy is the key among the treatment methods, and standardized antiviral therapy should be administered as long as there is an indication and conditions allow”. A few women with chronic hepatitis B will have an acute attack of hepatitis during pregnancy, and if left untreated, the condition can deteriorate dramatically and even develop liver failure, and some patients undergoing antiviral therapy have an unplanned pregnancy, and termination of antiviral therapy can result in an attack of hepatitis. Generally speaking, women of childbearing age with normal liver function are not recommended for antiviral treatment for the time being, and try to undergo antiviral treatment when necessary after childbirth, both injectable interferon and oral antiviral drugs have indications and regimen requirements, and try not to get pregnant during antiviral treatment to avoid the impact on the fetus. However, it should be noted that the following cases are considered as appropriate: 1, pregnant women with repeated abnormal liver function, and in pregnancy, liver function damage is obvious or even occur heavy liver, and HBVDNA is positive need to consider oral antiviral therapy. 2, has given birth to a child who is infected with hepatitis B, and the pregnant woman with a high level of HBVDNA, it is recommended to consider antiviral treatment for re-birth. 3, has been on oral antiviral therapy, but has not reached the criteria for discontinuation, after discontinuation of the drug may have a relapse of the disease, and want to have children, it is recommended to switch to a pregnancy safety class B drugs such as tipivudine, tenofovir or lamivudine to continue treatment, but should be carefully considered comprehensive. 4. Those who become pregnant while undergoing interferon antiviral therapy must terminate the pregnancy. To get pregnant must be more than six months after stopping interferon. We hope that those who have such needs will go to a regular hospital to consult a doctor to understand the treatment. May all mothers in the world have a healthy and lively child!