“Can hepatitis B be cured?” This is the most important question for patients with chronic hepatitis B. It is understandable, but it is a pity that there are a few patients who give up treatment and lose the opportunity for treatment because they have doubts about it. It is true that chronic hepatitis B is still a difficult disease to treat, especially in the antiviral aspects of many difficulties, therefore, claiming that “how much time package treatment” “major and minor triplets are turned negative” is unrealistic, but also unscientific, should not be gullible. However, chronic hepatitis B is by no means an incurable disease. First of all, we need to have a psychological orientation to “cure”, “big and small triplets all turn negative” is not the standard of “cure” for hepatitis B, China and the world’s chronic hepatitis B prevention and treatment guidelines are not “The overall goal of the treatment proposed in China’s guidelines for the prevention and treatment of chronic hepatitis B (2010 edition) is to maximize the long-term suppression of HBV (hepatitis B virus), reduce inflammatory necrosis of hepatocytes and liver fibrosis, delay and reduce liver decompensation, cirrhosis, HCC (hepatocellular carcinoma) and its complications, and thus improve the quality of life. The most fundamental and important of these is to improve the quality of life and prolong the survival time. The most fundamental and important of these is the maximum long-term suppression of HBV (hepatitis B virus). So, with treatment, can this goal be achieved? The 2009 Annual European Liver Conference suggested that with current antiviral therapy, chronic hepatitis B can achieve three outcomes: 1. The basic outcome – a sustained undetectable hepatitis B viral load (HBV DNA quantification), i.e., below the detection value. Most hospitals in China have a minimum detection value of 1000 or 500 copies/mL, and a few hospitals can be lower. 2.Satisfactory efficacy — (on the basis of the basic efficacy) to achieve the serological conversion of e antigen – e antibody, that is, commonly known as “major tri-positive” to “minor tri-positive”. 3. Ideal efficacy – the disappearance of surface antigen or the subsequent positive surface antibody, i.e., the serological conversion of surface antigen-surface antibody. This is the closest to the most ideal state of complete cure of hepatitis B, the virus is cleared. At present, the level of treatment of chronic hepatitis B in China is comparable to the international level, and with the application of existing antiviral drugs and after standardized treatment, a considerable number of patients can achieve basic efficacy or satisfactory efficacy, and some patients can also achieve ideal efficacy. In conclusion, although chronic hepatitis B is difficult to treat, but not incurable, the key is to treat timely and standardized, and with the development of medical science and the accumulation of experience in medical practice, the effect of hepatitis B treatment will be better and better.