First leap: 1910 by Prof. K. Schwarz: “No acid, no ulcers”. Second leap: “No HP, no ulcers” by Prof. Warren*Marshall in 1983. The third leap: In 1983 Prof. Tarnawski proposed: “Quality of Ulcer Healing (QOUH) ——- healing of ulcers requires not only gross healing but also restoration of their normal tissue structure and function in order to improve mucosal defenses and further reduce recurrence.” .