Helicobacter pylori is treated with a four-pronged approach, i.e., one drug to inhibit gastric acid secretion, one gastric mucosal protector and two antibiotics, as follows: first, gastric mucosal protector has the property of colloid, which can form a protective layer on the surface of the gastric mucosa, respectively colloidal bismuth such as aluminum carbonate gel, as well as prostaglandins and their derivatives, thioglycollate, and gefalconate. Secondly, the drugs that inhibit gastric acid secretion are mainly azoles, including omeprazole, rabeprazole, pantoprazole, which are often used in combination with drugs that protect the gastric mucosa because gastric acid can cause irritation to the gastric mucosa. Third, antibiotics need to be selected according to the patient’s drug resistance, commonly used penicillin, clarithromycin, amoxicillin, if you are allergic to amoxicillin and penicillin, you can choose metronidazole or ofloxacin.