The treatment of plasma cell tumor mainly includes the following aspects: 1, drug therapy: because plasma cell tumor is more sensitive to hormone, clinical usually use hormone with common chemotherapy drugs for treatment, currently bortezomib-based combination chemotherapy as the first-line treatment program; 2, targeted therapy: the current rapid development of clinical targeted therapy, the types of drugs gradually increased and better efficacy, so that the treatment of plasma cell tumor has gained greater progress, such as CD38 monoclonal antibody; 3, CAR-T therapy: for chemotherapy and targeted therapy have no significant effect, as well as relapsed refractory plasma cell tumor, it is recommended to choose CAR-T therapy, the treatment effect is good.