Non-parasitic liver cysts are relatively common benign diseases of the liver, congenital liver cysts are the most common, but there are also acquired ones, such as traumatic, inflammatory, and neoplastic cysts. Advantages Image guided percutaneous puncture has a high success rate, can be repeated, and can avoid important organs and large blood vessels, reducing complications. The aspirated cystic fluid can be subjected to bacterial culture and drug sensitivity test, which can help further diagnosis of etiology. Clinical application Liver cysts that cause symptoms are indications for this method. Larger cysts are not easily removed completely by surgery and are prone to recurrence after surgery. Puncture aspiration alone can recur shortly and is not effective. Image guided percutaneous puncture injection of sclerosing agent for liver cysts is more convenient, because ethanol has the advantages of high activity, low toxicity, fast action, fast absorption and cheap, and contact with the cyst wall for 1 to 3 min can make the epithelium fixed, so the clinical use of anhydrous ethanol as sclerosing agent.