Glucocorticoids are a “double-edged sword” in the treatment of rheumatoid arthritis. If used properly, hormones can effectively reduce inflammation and relieve the disease. Otherwise, they can cause significant side effects. Generally speaking, hormones are not the first choice for the treatment of rheumatoid arthritis. However, they can be used in the following four cases: 1. those with extra-articular manifestations such as systemic vasculitis, multi-organ damage, severe anemia, fever, eye and central nervous system damage, etc. 2. transitional treatment. In patients with severe rheumatoid arthritis, small amounts of hormones can be used to relieve the condition. 3. Patients who have not been treated with regular slow-acting anti-rheumatic drugs. 4. Local application. Such as intra-articular injection can effectively relieve the inflammation of the joint. Recent studies have concluded that small doses (≤7.5/day) of prednisone can relieve joint symptoms in patients with rheumatoid arthritis and may slow down the erosive changes in the joints. It can generally be 10-20 mg/day, and the hormone is reduced to as low as 2.5 mg/day once the disease is in remission. The duration of treatment can be as long as 1-2 years. Patients with rheumatoid arthritis, even if clinically indicated for the use of glucocorticoids, should be contraindicated or used with caution in the following circumstances Prohibited range: Patients with rheumatoid arthritis with acute gastrointestinal ulceration, bleeding or perforation, sepsis, active tuberculosis, severe diabetes mellitus and limited septic lesions. Scope of caution: Patients with rheumatoid arthritis with mild hypertension, mild diabetes, history of ulcer, osteoporosis, cataract, etc.