Skin bumps on the palms of the hands have different causes, such as insect bites, bacterial infections leading to folliculitis, or allergic reactions, viral infections leading to herpes, viral warts, eczema and other phenomena. However, when patients experience discomfort such as increased pain, redness or tingling on the skin surface or increased skin temperature, they need to be seen by a dermatologist immediately for relevant tests to identify the cause and treat it promptly.