Langerhans histiocytosis (LCH) refers to a group of diseases their primary pathology is characterized by an abnormal polygenic proliferation of Langerhans cells, Langerhans cells are characteristic of this group of diseases, which are macrophages normally present in the skin tissue. This disease manifests clinically in three different states: eosinophilic granulomatosis (EG); Han-She-Co syndrome (HSC) and Leucer’s syndrome (LS). there are various methods of clinical staging of LCH, the current recommendation of the Histiocyte Society is that LCH is divided into three stages: stage I: single lesion; stage II: multiple lesions; stage III: multiple lesions with visceral invasion.
Langerhans histiocytosis (LCH) is a rare disease that clinically causes destruction of bone tissue throughout the body. In this paper, a group of clinical data was studied to explore the radiation treatment options, the optimal dose of radiation therapy, and the prognosis of patients with LCH. METHODS: A retrospective study of 40 patients diagnosed with LCH with bone tissue lesions admitted to our department from 1986-2008, 20 patients with stage I with 20 radiotherapy sites, 17 patients with stage II with 22 radiotherapy sites, and 3 patients with stage III. Local irradiation of local bone lesions was performed with X-rays and electron rays in the dose range of 9-40 Gy with a split dose of 1.5-2 Gy. RESULTS: Two-year local control rate lesions of stage I patients were 100% and 5-year survival rate was 100%. 5-year survival rate of stage II patients was 87% (14/16). local control rate of stage II patients with radiotherapy doses greater than 20 Gy was 75% (3/4); 10 The local control rate was 92% (12/13) for doses less than 20 Gy and 75% (3/4) for doses less than 10 Gy. The 5-year survival rate for stage III patients was 67% (2/3). stage III patients received doses less than 10 Gy, and the 2-year local control rate was 100% (3/3). Conclusion: Doses less than 10 Gy can effectively control local lesions without serious complications, and 3D conformal radiotherapy is an effective means of treating local bone lesions in LCH and residual lesions after chemotherapy and surgery.