Antidepressants that can help with sleep are currently commonly used drugs such as agomelatine, mirtazapine, trazodone, etc. These drugs can not only effectively relieve the problem of depression, their efficacy is better and can help with sleep and solve the problem of insomnia. Different antidepressants have different mechanisms of action and work differently. For example, the commonly used agomelatine is a melatonin receptor agonist, which can effectively relieve the symptoms of depression, and at the same time has the effect of helping sleep, solving insomnia and improving sleep structure, and has been used clinically as a common drug for patients with insomnia and depression. However, these drugs are prescription medications and must be taken by a doctor in person, according to the patient’s specific symptoms and performance, individualized and targeted medication treatment, and never on your own.