Swelling of the face caused by lack of sleep is considered as heart function, kidney function or liver is affected. Consider the following aspects: First, heart function, lack of sleep or frequent late nights lead to the heart not getting a good rest, resulting in changes in heart function, causing changes in blood pressure and blood circulation. Second, kidney function, long-term insomnia leads to changes in kidney function, resulting in imbalance in filtration function, causing water and sodium retention, and imbalance in water metabolism in the body leading to swelling of the face. Third, liver function, due to the decline of liver function or the development of cirrhosis may also lead to swelling of the face. Fourthly, considering the causes of both lymphatic system and blood proteins, you can go to the hospital to check urine routine or blood pressure monitoring to determine whether there is a deficiency of liver, kidney and heart functions. In summary, puffiness of the face caused by lack of sleep may be caused by changes in the heart, kidneys, and liver.