Hypertension with variant angina is preferred to diltiazem or nifedipine drugs, which have the effect of lowering blood pressure, but also have the effect of antiplatelet, dilate the heart blood vessels, and delay the heart vascular spasm. Variable angina is often accompanied by vasospasm, so taking calcium antagonist antihypertensive drugs is preferred. If the number of angina attacks cannot be controlled by calcium antagonists alone, nitroglycerin or cardiodilators can be added. For the treatment of variant angina, beta-blockers should not be used. Although beta-blockers can inhibit or reduce myocardial excitability, lower blood pressure and reduce myocardial contractility, when using beta-blockers, the vasodilating effect of beta receptors is blocked and the constricting effect of alpha receptors is relatively enhanced, which may induce and aggravate arterial spasm. If variant angina becomes progressively worse, this is often the time when a combination of many anti-anginal drugs is required.