Sore thighs may be caused by the following problems: 1. Sore thighs caused by thigh strain and strain injury. 2. May be local aseptic inflammation, such as femoral head necrosis, synovitis, and aseptic inflammation of the acetabulum, all of which may cause sore thighs. 3. May be herniated discs, lumbar spinal stenosis, and these lumbar spine problems compressing nerves causing sore thighs, especially the high level of herniated discs. 4. 5, may also be thigh muscle strains, fasciitis, and even tuberculosis, tumors, may cause thigh soreness.