Cranial defects have a serious impact on the patient’s quality of life as well as appearance, so it is important to repair the skull as soon as possible. The choice of repair material for cranial defects is crucial, and the correct choice of repair material can not only improve the success rate of surgery, but also reduce the pain of patients. At present, most hospitals choose titanium mesh as the cranial bone repair materials, titanium mesh for cranial bone repair, patients should be prohibited from engaging in high temperature, low-temperature work, because the titanium mesh hot and cold reaction is obvious, high temperature will burn the soft tissue or skin of the brain, the low temperature will also be the soft tissue of the brain will bring harm. It is recommended that patients suffering from brain diseases prohibit the use of titanium mesh for cranial bone repair, and choose PEEK material for cranial bone repair, because PEEK material can be reused under high temperature sterilization, which will reduce the cost pressure on the patients to a certain extent. PEEK material for skull repair has been a very mature material for neurosurgery, in many countries has been widely used, at present in the country, a few regular tertiary hospitals have used PEEK material for skull repair. Because PEEK material for cranial bone repair through 3D printing, according to the patient’s cranial defects for personalized perfect shaping, while largely shortening the operating time. Our team uses PEEK material to do cranial bone repair surgery, achieved good clinical results, recognized and praised by patients.