Cranial defects sound scary, after all, a good missing piece of the head is certainly not good, not to mention the aesthetic impact, but also damage to health. Because the skull is the brain’s external protective barrier, only the skull is intact to avoid the brain tissue by the outside world. Therefore, when encountering the problem of cranial defects, the thing to do is to go to the hospital in time to do cranial bone repair surgery. Many people should not be unfamiliar with cranial bone repair surgery, which is a classic procedure in neurosurgery, has been available at a very early stage, and the development has been technically quite mature. Patients who are troubled by cranial defects need to go to a regular hospital and let experienced and skillful specialists arrange the surgery for them. Can cranial bone repair achieve the original appearance, will affect the aesthetic? Whether skull repair can achieve good results is not only related to the choice of repair materials, but also related to the skill of the surgeon. Currently, most hospitals use titanium mesh material for skull repair surgery. Compared with other materials in the early days, titanium mesh material is progressive, but there are still some unavoidable problems. For example, there is the possibility of postoperative rejection, susceptibility to infection, postoperative sensitivity to hot and cold environments, and the risk of exposure of the material. In order to make up for these shortcomings, a new type of polyether ether ketone PEEK material appeared, the material’s performance is comparable to the autologous skull, but also according to the shape of the patient’s defective bone window for personalized three-dimensional shaping custom, highly restored to the cranial morphology, the postoperative recovery is ideal, the effect is natural and beautiful. At present, our team is using PEEK material to carry out surgery for the majority of patients, and we have also carried out technological innovation and material optimization design, the introduction of the concept of aesthetic plastic surgery, to truly achieve the organic unity of the structural restoration, functional perfection, and aesthetically pleasing appearance.