The causes of neonatal heart failure, i.e. congenital heart disease, are a combination of genetic, physical, chemical, biological and maternal pregnancy factors. 1. Genetic factors: If the parents have congenital heart disease, the probability of the child’s congenital heart disease will be higher. 2. Physical factors: air pollution, including electromagnetic radiation, can cause an increase in the prevalence of congenital heart disease in newborns. 3. Chemical factors: the intake of heavy metals and pesticides can also increase the incidence. 4. Biological factors: Mothers infected with cytomegalovirus, rubella virus, herpes, and herpes simplex virus in the early or mid-pregnancy period can lead to an increase in the prevalence of congenital heart disease in their children. 5. Gestational disorders: These include high blood pressure, gestational diabetes mellitus, and maternal hypothyroidism and hyperthyroidism, which are also important causes of congenital heart disease. Newborns with an unclosed heart need active intervention or follow up with a doctor.